Neuronutraceuticals Modulate Lipopolysaccharide- or Amyloid-β 1-42 Peptide-Induced Transglutaminase 2 Overexpression as a Marker of Neuroinflammation in Mouse Microglial Cells

Background: Tissue type 2 transglutaminase (TG2, E.C. 2.3.2,13) is reported to be involved in the phagocytosis of apoptotic cells mouse microglial BV2 and peripheral macrophages. In this study, by using lipopolysaccharide (LPS)- or amyloid-β 1-42 (Aβ 1-42) peptide-stimulated cell line primary cells, we examined effects different neuronutraceutical compounds, such as curcumin (Cu) N-Palmitoylethanolamine (PEA), known for their anti-inflammatory activity, on TG2 several inflammatory neuroprotective biomarker expressions. Methods: Mouse were treated with LPS Aβ1-42 presence PEA, order evaluate expression other markers Real Time-PCR Western blot analyses. Results: Curcumin PEA capable reducing during co-treatment Aβ 1-42. Conclusions: The results show role an important marker neuroinflammation suggest a possible use reduce LPS- Aβ1-42-induced overexpression cells.